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Fig. 7 | Cancer Cell International

Fig. 7

From: Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer

Fig. 7Fig. 7

Comprehensive Bioinformatics Analysis of FBXO1 and Co-expressed Genes in BC. a High expression of FBXO1 protein in different subtypes of BC verified by immunohistochemistry. Scale bar = 50 μm, T, tumor tissues; N, normal tissues. b The percentages of mutation types of FBXO1 in BC were indicated in a pie chart generated from Catalogue of Somatic Mutations in COSMIC database. c, d The top 150 genes positively associated with FBXO1 transcript level based on the cBioPortal and COXPRESdb databases in BC. The tables listed the top 20 genes. e Venn diagram represented the intersection of top positively corrected genes between the cBioPortal and COXPRESdb databases. f The bubble diagram showed the functions of FBXO1 and 108 genes significantly associated with FBXO1 alterations, which were predicted by the analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) by STRING tools. g Gene Ontology (GO) enrichment analysis predicted the functional roles of FBXO1 and 108 co-expressed genes based on three aspects, including biological processes (BP), cellular components (CC) and molecular function (MF)

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