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Table 1 Cytokines and mediators secreted from MSCs during cross-talk with tumor cells responsible for homing, growth, and stemness in tumor cells

From: Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature

Effect Mediator type Mediator References
Homing of MSC in tumor Cytokine TNF-α [132, 133]
IFN-γ [132]
IL-1β [132]
IL-6 [29]
IL-8 [134]
Chemokine SDF-1/CXCR4 [135, 136]
MCP-1 [137]
GRO-α [134]
Growth factor TGF-β [138]
PGF [139]
PDGF [132]
HGF [132]
MSC-mediated tumor growth (metastasis and proliferation) Cytokine IL-6 [38, 140]
IL-10 [140]
TNF-α [140]
Chemokine CCL5 [31, 141]
CXCL1 [142]
CXCL2 [142, 143]
CXCL3 [142]
CXCL5 [142]
CXCL6 [142]
CXCL8 [116, 142]
CCL2 [142]
CCL8 [142]
CCL20 [142]
Growth factor IGF-1 [144]
TGFβ1 [145]
HGF [146]
MSC-mediated cancer cell stemness Cytokine IL-1α [147]
IL-1β [147]
IL-6 [147, 148]
Chemokine CXCL1 [147]
CXCL8 [147]
CXCL1 [29]
CXCL5 [29]
CXCL6 [29]
CXCL7 [29]
CCL5 [141]
Growth factor BMP4 [35]
PGE2 [147]
  1. MSC Mesenchymal stem cell, TNF tumor necrosis factor, IFN interferon, IL interleukin, SDF stromal cell-derived factor, MCP monocyte chemoattractant protein, GRO growth-regulated oncogene, TGF transforming growth factor, PGF placental growth factor, PDGF platelet-derived growth factor, HGF hepatocyte growth factor, BMP4 bone morphogenetic protein, IGF-1 insulin-like growth factor-1, PGE2 prostaglandin E2