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Fig. 5 | Cancer Cell International

Fig. 5

From: The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma

Fig. 5

LIN7A expression in NB correlates with survival and stage. a LIN7 gene family expression in NB patient dataset (GSE49710) stratified by survival (b) LIN7A gene expression stratified by INSS stage. Cell responses 48 h post LIN7A over expression (LIN7A-GFP) or silencing (si-LIN7A) in SKNAS cells showing: c proliferation; d viable and non-viable cell fraction. e LIN7A gene expression analysis 48 h post LIN7A over expression (LIN7A-GFP) or silencing (si-LIN7A) in NB cells (SKNAS). f BAX g BCL2 and h BAX/BCL2 ratio gene expression, and i Western blot showing LIN7A, BAX and BCL2 protein levels, in NB cells after LIN7A over expression (LIN7A-GFP) or silencing (si-LIN7A). The data shown is the pooled average of 3 experiments. The data in c and d are shown as the mean ± SD. The data in (eh) are presented as Tukeys box and whisker plots showing IQR, line at the median, + at the mean with whiskers ± 1.5-fold of interquartile range *p < 0.05, **p < 0.01, ***p < 0.001, ns = not significant

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