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Table 2 Univariable and multivariable Cox regression analysis of the circRNA signature and survival of ESCCs in the training and test group

From: RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma

   Univariable analysis Multivariable analysis
Variables HR 95% CI of HR P HR 95% CI of HR P
Lower Upper Lower Upper
Training dataset (n = 73)
 Sex Male vs. Female 1.375 0.718 2.635 0.337 1.336 0.682 2.617 0.398
 Age > 62 vs. ≤ 62 1.241 0.667 2.311 0.495 1.585 0.819 3.066 0.171
 pTNM stage III, IV vs. I, II 2.424 1.362 4.314 0.003 1.639 0.884 3.039 0.117
 circRNA-signature High risk vs. low risk 7.746 3.519 17.051 0.000 6.705 2.951 15.237 0.000
Test set (n = 125)
 Sex Male vs. Female 1.185 0.659 2.130 0.570 1.109 0.614 2.003 0.732
 Age > 62 vs. ≤ 62 0.987 0.543 1.793 0.966 1.084 0.596 1.974 0.791
 pTNM stage III, IV vs. I, II 1.825 1.163 2.863 0.009 1.635 1.032 2.590 0.036
 circRNA signature High risk vs. low risk 2.794 1.484 5.260 0.001 2.583 1.363 4.896 0.004
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