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Table 2 Univariable and multivariable Cox regression analysis of the circRNA signature and survival of ESCCs in the training and test group

From: RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma

  

Univariable analysis

Multivariable analysis

Variables

HR

95% CI of HR

P

HR

95% CI of HR

P

Lower

Upper

Lower

Upper

Training dataset (n = 73)

 Sex

Male vs. Female

1.375

0.718

2.635

0.337

1.336

0.682

2.617

0.398

 Age

> 62 vs. ≤ 62

1.241

0.667

2.311

0.495

1.585

0.819

3.066

0.171

 pTNM stage

III, IV vs. I, II

2.424

1.362

4.314

0.003

1.639

0.884

3.039

0.117

 circRNA-signature

High risk vs. low risk

7.746

3.519

17.051

0.000

6.705

2.951

15.237

0.000

Test set (n = 125)

 Sex

Male vs. Female

1.185

0.659

2.130

0.570

1.109

0.614

2.003

0.732

 Age

> 62 vs. ≤ 62

0.987

0.543

1.793

0.966

1.084

0.596

1.974

0.791

 pTNM stage

III, IV vs. I, II

1.825

1.163

2.863

0.009

1.635

1.032

2.590

0.036

 circRNA signature

High risk vs. low risk

2.794

1.484

5.260

0.001

2.583

1.363

4.896

0.004

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Cancer Cell International

ISSN: 1475-2867

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