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Table 2 The pooled result of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG in the diagnosis of NPC

From: The diagnostic value of EBV-DNA and EBV-related antibodies detection for nasopharyngeal carcinoma: a meta-analysis

Method Pooled sensitivity (95% CI) Pooled specificity (95% CI) Pooled PLR (95% CI) Pooled NLR (95% CI) Pooled DOR (95% CI) AUC (SE)
EBV-DNA 0.76 0.96 14.66 0.19 84.00 0.96
0.73–0.77 0.95–0.97 9.97–21.55 0.13–0.28 50.45–139.88 0.0011
EA-IgA 0.55 0.96 12.91 0.35 39.57 0.94
0.54–0.57 0.96–0.97 9.55–17.45 0.29–0.43 26.44–59.23 0.00274
VCA-IgA 0.85 0.89 6.73 0.17 43.03 0.93
0.84–0.85 0.88–0.89 5.38–8.43 0.12–0.23 31.51–58.76 0.0076
EBNA1-IgA 0.86 0.87 7.55 0.16 50.95 0.94
0.85–0.88 0.88–0.90 5.79–9.87 0.13–0.19 34.35–75.57 0.0089
Rta-IgG 0.70 0.94 9.84 0.25 40.59 0.95
0.69–0.7149 0.94–0.95 8.40–11.54 0.21–0.31 32.09–51.35 0.0052