Table 2 The pooled result of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG in the diagnosis of NPC
Method | Pooled sensitivity (95% CI) | Pooled specificity (95% CI) | Pooled PLR (95% CI) | Pooled NLR (95% CI) | Pooled DOR (95% CI) | AUC (SE) |
|---|---|---|---|---|---|---|
EBV-DNA | 0.76 | 0.96 | 14.66 | 0.19 | 84.00 | 0.96 |
0.73–0.77 | 0.95–0.97 | 9.97–21.55 | 0.13–0.28 | 50.45–139.88 | 0.0011 | |
EA-IgA | 0.55 | 0.96 | 12.91 | 0.35 | 39.57 | 0.94 |
0.54–0.57 | 0.96–0.97 | 9.55–17.45 | 0.29–0.43 | 26.44–59.23 | 0.00274 | |
VCA-IgA | 0.85 | 0.89 | 6.73 | 0.17 | 43.03 | 0.93 |
0.84–0.85 | 0.88–0.89 | 5.38–8.43 | 0.12–0.23 | 31.51–58.76 | 0.0076 | |
EBNA1-IgA | 0.86 | 0.87 | 7.55 | 0.16 | 50.95 | 0.94 |
0.85–0.88 | 0.88–0.90 | 5.79–9.87 | 0.13–0.19 | 34.35–75.57 | 0.0089 | |
Rta-IgG | 0.70 | 0.94 | 9.84 | 0.25 | 40.59 | 0.95 |
0.69–0.7149 | 0.94–0.95 | 8.40–11.54 | 0.21–0.31 | 32.09–51.35 | 0.0052 |