Fig. 4
From: Role of m6A methyltransferase component VIRMA in multiple human cancers (Review)
Mechanisms of VIRMA and circ_KIAA1429 involved in human cancer progression. VIRMA expression could be regulated by miR-143-3p. VIRMA played an important role in tumor cell proliferation, invasion, migration, cell cycle, metastasis, apoptosis resistance, tumorigenesis in an m6A-dependent or m6A-independent manner. The TGF-β, cell cycle, TNF and other signaling pathways were involved in the underlying mechanism. Circ_KIAA1429 can promote HCC through the mechanism of m6A-YTHDF3-Zeb1 pathway. VIRMA, vir-like m6A methyltransferase associated