Table 1 Characteristics of the 12 included studies
Authors | Years | Country | Adjusted factors | Number of cancer/dysplasia/GIM | Design | Follow-up time (years) | Age (years) ± SDa | NOS Score | Biopsy sampling protocols | Methods for discrimination of subtypes |
|---|---|---|---|---|---|---|---|---|---|---|
Cassaro [28] | 2000 | Italy | None | –/59/26 | Case–c ontrol | – | 48.6 ± 14.4 (cancer) 42.3 ± 11.5 (control) | 7 | 5 from antrum; 6 from corpus; 1 from cardia | AB-PAS; HID/AB |
González [29] | 2010 | Spain | None | –/17/175 | Cohort | Mean 12.8 | 50.0 ± 12.2 | 7 | 2 from antrum; 1 from incisura angularis; 2 from corpus | AB-PAS; HID/AB |
González [14] | 2015 | Spain | Sex, age, smoking, family history, use of NSAID | 27/22/418 | Cohort | Mean 12 | 52.17 ± 10.13 | 7 | At least 3 fragments, including both antrum and corpus | AB-PAS; HID/AB |
Mera [27] | 2017 | Colombia | OLGA and OLGIM systems | – | Cohort | Up to 16 | 51 ± 9 | 8 | 2 from antrum; 1 from incisura angularis; 1 from corpus | AB-PAS; HID/AB; H&E staining |
Pittayanon [30] | 2017 | Thailand | Hp, family history, smoking, drinking, preservative food consumption | 3/3/85 | Cohort | Mean 4.05 | 63 ± 13.3 | 8 | Targeted biopsies from suspicious lesions under NBI | H&E staining |
Rothery [31] | 1985 | UK | None | 17/52/420 | Case–control | – | 59 ± 16 | 8 | – | AB-PAS; HID/AB |
Silva [17] | 1986 | Portuguese | None | –/72/172 | Case–control | – | 28–86 (range) | 7 | 2–10 biopsies from antrum, corpus, and incisura angularis according to endoscopic findings | AB-PAS; HID/AB |
Ramesar [32] | 1987 | Scotland | None | –/2/42 | Cohort | 10 to 11 | 66 ± 9 (11–5) (type I) 64 ± 3 (12–9) (type II) 65 ± 4 (11–6) (type III) | 6 | – | AB-PAS; HID/AB |
Silva [33] | 1990 | UK | None | 6/1/116 | Cohort | Up to 6 year | – | 8 | 1 from antrum (chronic gastritis group) or ulcers (ulcer group); additional biopsy specimens were taken if necessary | AB-PAS; HID/AB |
Filipe [34] | 1994 | SLOVENIA | None | –/26/964 | Cohort | Up to 20 year | – | 7 | 2 from antrum; 1 from corpus | AB-PAS; HID/AB |
Wu [35] | 1998 | China | None | –/90/49 | Case–control | – | – | 8 | 2 from antrum; 1 from incisura angularis; 2 from corpus | HID/AB; H&E staining |
Kang [20] | 2009 | Korea | None | –/391/195 | Case–control | – | 57.7 ± 13.5 | 7 | 2 from antrum; 2 from corpus | AB-PAS; HID/AB |