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Table 1 Characteristics of the 12 included studies

From: A meta-analysis and systematic review on subtypes of gastric intestinal metaplasia and neoplasia risk

Authors Years Country Adjusted factors Number of cancer/dysplasia/GIM Design Follow-up time (years) Age (years) ± SDa NOS Score Biopsy sampling protocols Methods for discrimination of subtypes
Cassaro [28] 2000 Italy None –/59/26 Case–c ontrol 48.6 ± 14.4 (cancer)
42.3 ± 11.5 (control)
7 5 from antrum; 6 from corpus; 1 from cardia AB-PAS; HID/AB
González [29] 2010 Spain None –/17/175 Cohort Mean 12.8 50.0 ± 12.2 7 2 from antrum; 1 from incisura angularis; 2 from corpus AB-PAS; HID/AB
González [14] 2015 Spain Sex, age, smoking, family history, use of NSAID 27/22/418 Cohort Mean 12 52.17 ± 10.13 7 At least 3 fragments, including both antrum and corpus AB-PAS; HID/AB
Mera [27] 2017 Colombia OLGA and OLGIM systems Cohort Up to 16 51 ± 9 8 2 from antrum; 1 from incisura angularis; 1 from corpus AB-PAS; HID/AB; H&E staining
Pittayanon [30] 2017 Thailand Hp, family history, smoking, drinking, preservative food consumption 3/3/85 Cohort Mean 4.05 63 ± 13.3 8 Targeted biopsies from suspicious lesions under NBI H&E staining
Rothery [31] 1985 UK None 17/52/420 Case–control 59 ± 16 8 AB-PAS; HID/AB
Silva [17] 1986 Portuguese None –/72/172 Case–control 28–86 (range) 7 2–10 biopsies from antrum, corpus, and incisura angularis according to endoscopic findings AB-PAS; HID/AB
Ramesar [32] 1987 Scotland None –/2/42 Cohort 10 to 11 66 ± 9 (11–5) (type I)
64 ± 3 (12–9) (type II)
65 ± 4 (11–6) (type III)
6 AB-PAS; HID/AB
Silva [33] 1990 UK None 6/1/116 Cohort Up to 6 year 8 1 from antrum (chronic gastritis group) or ulcers (ulcer group); additional biopsy specimens were taken if necessary AB-PAS; HID/AB
Filipe [34] 1994 SLOVENIA None –/26/964 Cohort Up to 20 year 7 2 from antrum; 1 from corpus AB-PAS; HID/AB
Wu [35] 1998 China None –/90/49 Case–control 8 2 from antrum; 1 from incisura angularis; 2 from corpus HID/AB; H&E staining
Kang [20] 2009 Korea None –/391/195 Case–control 57.7 ± 13.5 7 2 from antrum; 2 from corpus AB-PAS; HID/AB
  1. aAge distribution of all subjects in related studies
  2. AB-PAS Alcian blue pH 2.5/periodic acid Schiff; HID/AB high iron-diamine/Alcian blue pH 2.5; H&E haematoxylin and eosin; NBI narrow-band imaging
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