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Fig. 2 | Cancer Cell International

Fig. 2

From: miR-320a/SP1 negative reciprocal interaction contributes to cell growth and invasion in colorectal cancer

Fig. 2

miR-320a inhibited CRC cell growth and invasion in vitro and tumor growth in vivo. a Restoration of miR-320a by introducing mimics significantly inhibited cell growth in SW480 and SW620 cells during a 96 h observation. *P < 0.05 vs miR-NC; **P < 0.01 vs miR-NC. b In colony formation assays, restoration of miR-320a caused inhibitory effects on cell colony formation in SW480 (P = 0.006) and SW620 (P = 0.0302) cells compared with negative controls. c Restoration of miR-320a significantly inhibited cell invasion in SW480 (P = 0.0145) and SW620 (P = 0.0018) cells. In a xenograft mouse model (n = 4 per group), mice bearing stable miR-320a-expressing SW620 cells exhibited significant reduction of tumor volume ex vivo (d) and tumor growth in vivo (P = 0.021) compared with negative controls (e)

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Cancer Cell International

ISSN: 1475-2867

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