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Fig. 3 | Cancer Cell International

Fig. 3

From: Elevation of miR-302b prevents multiple myeloma cell growth and bone destruction by blocking DKK1 secretion

Fig. 3

DKK1 as a direct target of miR-302b in MM cells. a Sequence alignment of predicted miR-302b binding sites within the DKK1 3′UTR and its mutated sequence for luciferase reporter assay. b, c Luciferase reporter assay was performed in RPMI 8226 cells and MM1.S cells that were co-transfected with miR-302b mimics and reporter vectors containing DKK1 3′UTR or mutated DKK1 3′UTR. Relative luciferase activity is presented. *P < 0.05 vs. NC group. Data are presented as mean ± SD from three separated experiments. d, e Expression of DKK1 in RPMI 8226 and MM1.S cells after the transfection of miR-302b mimic and mimic control

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Cancer Cell International

ISSN: 1475-2867

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