Fig. 8

Macrophages-derived exosomes promote osteosarcoma growth and metastasis in vivo. a The effect of Mφ-Exos on the growth of tumors was detected on xenograft. b The growth curve of xenograft. c The tumor weight of xenograft. d The lung metastasis model was established via a tail vein injection of osteosarcoma cells. e–f Metastatic tumor nodules were observed by H&E staining. g IHC was performed to detect the expression of proteins. **p < 0.01