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Table 2 The expression percentage of CD44, CD166, and CD133 common CRC-CSCs markers in spheroids compared to their parental cells

From: Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines

Markers Cell types
HT-29 Caco-2
Parental Spheroid Parental Spheroid
CD44% 1.80 ± 0.77 19.3 ± 6.60* 1.59 ± 0.28 41.05 ± 3.53***
CD133% 1.35 ± 0.19 11.75 ± 4.69* 1.25 ± 0.45 28.25 ± 17.45*
CD166% 1.66 ± 0.37 22.40 ± 5.92* 1.78 ± 0.18 37.15 ± 4.02***
  1. Data are shown as mean ± SD of four independent experiments. A significant upregulation of CSC markers in spheroids compared to parental cells are presented as * = P < 0.05, *** = P < 0.001, ns = not significant