Skip to main content

Table 1 List of studies on the cross-talk between MUC1 and VEGFR proteins in various cancers

From: Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling

Cross-talk evidence Cancer type References
Stimulation of synthesis and secretion of VEGF through AKT and ERK1/2 signaling pathways by MUC1 expression Human breast carcinoma [39]
Induction of NRP1-dependent VEGFR signaling and angiogenesis by modulating TA-MUC1 Pancreatic ductal adenocarcinoma cells [96]
Strong co-expression of VEGF-A and MUC-1 in neoangiogenesis of Invasive micropapillary carcinoma cells Invasive micropapillary colorectal carcinoma [88]
MUC1 overexpression was frequent in cases with up-regulated VEGF/KDR angiogenic pathway in the sample patients Non-small cell lung cancer [87]
Co-transcription of MUC1 and VEGF mRNA in blood samples of patients with advanced non-small cell lung cancer Non-small cell lung cancer [98]
Increasing VEGF expression in MUC1-overexpressing NSCLC cells through phosphorylated Akt and ERK1/2 pathways Non-small-cell lung cancer cells [99]
Decreasing expression of VEGF by MUC-1 inhibition Non-small-cell lung cancer cells [89]