Table 1 List of studies on the cross-talk between MUC1 and VEGFR proteins in various cancers
Cross-talk evidence | Cancer type | References |
|---|---|---|
Stimulation of synthesis and secretion of VEGF through AKT and ERK1/2 signaling pathways by MUC1 expression | Human breast carcinoma | [39] |
Induction of NRP1-dependent VEGFR signaling and angiogenesis by modulating TA-MUC1 | Pancreatic ductal adenocarcinoma cells | [96] |
Strong co-expression of VEGF-A and MUC-1 in neoangiogenesis of Invasive micropapillary carcinoma cells | Invasive micropapillary colorectal carcinoma | [88] |
MUC1 overexpression was frequent in cases with up-regulated VEGF/KDR angiogenic pathway in the sample patients | Non-small cell lung cancer | [87] |
Co-transcription of MUC1 and VEGF mRNA in blood samples of patients with advanced non-small cell lung cancer | Non-small cell lung cancer | [98] |
Increasing VEGF expression in MUC1-overexpressing NSCLC cells through phosphorylated Akt and ERK1/2 pathways | Non-small-cell lung cancer cells | [99] |
Decreasing expression of VEGF by MUC-1 inhibition | Non-small-cell lung cancer cells | [89] |