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Table 1 List of studies on the cross-talk between MUC1 and VEGFR proteins in various cancers

From: Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling

Cross-talk evidence

Cancer type


Stimulation of synthesis and secretion of VEGF through AKT and ERK1/2 signaling pathways by MUC1 expression

Human breast carcinoma


Induction of NRP1-dependent VEGFR signaling and angiogenesis by modulating TA-MUC1

Pancreatic ductal adenocarcinoma cells


Strong co-expression of VEGF-A and MUC-1 in neoangiogenesis of Invasive micropapillary carcinoma cells

Invasive micropapillary colorectal carcinoma


MUC1 overexpression was frequent in cases with up-regulated VEGF/KDR angiogenic pathway in the sample patients

Non-small cell lung cancer


Co-transcription of MUC1 and VEGF mRNA in blood samples of patients with advanced non-small cell lung cancer

Non-small cell lung cancer


Increasing VEGF expression in MUC1-overexpressing NSCLC cells through phosphorylated Akt and ERK1/2 pathways

Non-small-cell lung cancer cells


Decreasing expression of VEGF by MUC-1 inhibition

Non-small-cell lung cancer cells