Fig. 9

ARV-825 displays anti-tumor efficacy in the T-ALL xenograft model. Nude mice bearing CCRF xenograft tumors were treated by either 10 mg/kg ARV-825 or vehicle control intraperitoneally every day for 14 days. Data are mean ± SEM (n = 5). a Tumor volume was recorded every 2 days and calculated using the formula: (width × width × length)/2. b Mice body mass was weighed every 4 days. c Photograph of xenograft tumors from ARV-825- or vehicle-treated mice. d Tumor weight from ARV-825- or vehicle-treated mice. e Western blot analysis of BRD4 and c-Myc expression in tumors from ARV-825- or vehicle-treated mice. f IHC staining of Ki67 in xenograft tumors from ARV-825- or vehicle-treated mice. g IHC staining of cleaved-caspase 3 (cl-caspase 3) in xenograft tumors from ARV-825- or vehicle-treated mice