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Fig. 5 | Cancer Cell International

Fig. 5

From: Cyproheptadine, an epigenetic modifier, exhibits anti-tumor activity by reversing the epigenetic silencing of IRF6 in urothelial carcinoma

Fig. 5

IRF6 inhibits proliferation of UC in vivo. UMUC3 cells transfected with control (control) or plasmid expressing IRF6 (OV) were injected subcutaneously into athymic nude mice (BALB/cByJNarl). a Tumor size were monitored and measured for 15 days (left panel). Statistical significances were observed in IRF6-overexpressed compared with Control (**p < 0.01). Right panel shows the representative examples of tumors formed (red circle) in the control (right) and IRF6-overexpressed group (left) were also shown. b Significantly smaller dissected tumor on day 15 was also shown. Right panel shows the mean weight (means ± SD) of all the tumors

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Cancer Cell International

ISSN: 1475-2867

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