A nomogram for predicting survival of head and neck mucosal melanoma

Table 3 Univariate Cox regression analysis of DMFS and LRRFS in the primary cohort

Variable	DMFS		LRRFS
Variable	HR (95% CI)	P	HR (95% CI)	P
Gender
Male	Reference		Reference
Female	0.964 (0.717–1.297)	0.811	1.036 (0.793–1.355)	0.794
Age (years old)
< 60	Reference		Reference
≥ 60	1.246 (0.641–1.164)	0.134	1.070 (0.822–1.391)	0.616
Smoking
No	Reference		Reference
Yes	0.864 (0.625–1.236)	0.336	0.819 (0.609–1.100)	0.185
Primary site
Others	Reference		Reference
Nasal cavity	1.695 (1.084–2.649)	0.021^*	1.795 (1.128–2.858)	0.014^*
Paranasal sinus	3.736 (2.032–6.867)	< 0.001^***	3.710 (1.995–6.897)	< 0.001^***
Oral cavity	1.9844 (1.217–3.235)	0.006^**	2.631 (1.601–4.323)	< 0.001^***
8th T stage
T3	Reference		Reference
T4a	2.544(1.838–3.520)	< 0.001^***	1.945 (1.434–2.639)	< 0.001^***
T4b	10.314(6.861–15.502)	< 0.001^***	5.816 (4.002–8.452)	< 0.001^***
8th N stage
N0	Reference		Reference
N1	1.597 (1.180–2.161)	0.002^**	1.665 (1.231–2.253)	0.001^***
Surgery
No	Reference		Reference
Yes	0.758 (0.455–1.262)	0.286	0.664 (0.409–1.078)	0.098
Radiotherapy
No	Reference		Reference
Yes	1.359 (1.037–1.224)	0.026^*	1.007 (0.771–1.316)	0.957
Chemotherapy
No	Reference		Reference
Yes	1.022 (0.792–1.318)	0.869	0.934 (0.718–1.215)	0.611
Immunologic/targeted therapy
No	Reference		Reference
Yes	0.858 (0.634–1.161)	0.320	0.801 (0.594–1.079)	0.144

Cox proportional hazard model was used to conduct Cox regression analysis. * p value < 0.05; ** p value < 0.01; ** p value < 0.001

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