SNRPD1 confers diagnostic and therapeutic values on breast cancers through cell cycle regulation

Table 3 Classification of genes enriched in the cell cycle from Reactome pathways among the 434 SRTNS

M		M checkpoint		S	S checkpoint	Rest	Common
AAAS	NCAPG2	BUB1B	NDC80	CDCA5	CCNA2	BLM	PSMD3
CDCA5	NCAPH	CCNB1	NUF2	CUL1	CDC45	CDC7	PSMD14
CEP152	NCAPH2	CDC20	NUP107	FEN1	MCM2	CHEK1	RPS27A
HAUS1	NDC1	CDCA8	NUP133	PCNA	MCM3	GMNN
HAUS2	NUP153	CDK1	NUP160	POLA1	MCM4	MCM10
HAUS3	NUP155	CENPF	NUP85	POLA2	MCM5	MDC1
HAUS4	NUP205	CENPH	PLK1	POLE	MCM6	MND1
HAUS5	NUP210	CENPI	RCC2	PRIM1	MCM7	TOP3A
HAUS6	NUP50	CENPO	SKA1	PRIM2	ORC6	TOPBP1
HAUS8	NUP93	CENPQ	SPC24		RFC2	TPX2
KIF20A	SMC2	CENPU	SPC25		RFC4	WHSC1
MASTL	SMC4	ERCC6L	XPO1		RFC5
NCAPD2	VRK1	INCENP	ZW10
NCAPD3		KIF2C	ZWILCH
NCAPG		KNTC1	ZWINT

STRING version 11.0 was used to conduct the enrichment analysis. Experimentally tested genes are highlighted in bold face. ‘M’ and ‘S’ each represents genes specific the M and S phase, respectively. ‘M checkpoint’ and ‘S checkpoint’ each means genes specific to M and S phase check point regulation, respectively, which were obtained by taking the intersection of genes between ‘M phase’ or ‘S phase’ and ‘cell cycle checkpoint’ pathways. ‘Common’ and ‘Rest’ each represents genes present in and absent from all ‘M’, ‘M checkpoint’, ‘S’, ‘S checkpoint’ categories, respectively

ISSN: 1475-2867