Low expression of CHRDL1 and SPARCL1 predicts poor prognosis of lung adenocarcinoma based on comprehensive analysis and immunohistochemical validation

Table 3 Relative pathways associated with the expression of CHRDL1 and SPARCL1 using GSEA

Gene	Name	ES	NES	NOM p-value	FDR q-value
CHRDL1	GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR	− 0.55	− 1.93	< 0.0001	0.109
	GO_CELL_CYCLE_CHECKPOINT	− 0.51	− 1.93	0.006	0.107
	GO_DNA_UNWINDING_INVOLVED_IN_DNA_REPLICATION	− 0.81	− 1.93	< 0.0001	0.106
	GO_EXONUCLEASE_ACTIVITY	− 0.53	− 1.92	0.002	0.116
	GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS	− 0.53	− 1.92	0.006	0.114
	GO_TELOMERE_ORGANIZATION	− 0.54	− 1.91	0.002	0.114
	GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE	− 0.71	− 1.91	< 0.0001	0.114
	GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION	− 0.56	− 1.91	0.002	0.113
	GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX	− 0.73	− 1.91	0.002	0.112
	GO_DNA_BIOSYNTHETIC_PROCESS	− 0.47	− 1.91	0.002	0.112
SPARCL1	GO_ENDONUCLEASE_COMPLEX	− 0.68	− 2.17	< 0.0001	0.047
	GO_BASE_EXCISION_REPAIR	− 0.67	− 2.11	0.002	0.048
	GO_SPLICEOSOMAL_COMPLEX	− 0.6	− 2.1	< 0.0001	0.031
	GO_NCRNA_METABOLIC_PROCESS	− 0.59	− 2.1	< 0.0001	0.048
	GO_MITOTIC_SPINDLE_ORGANIZATION	− 0.61	− 2.09	< 0.0001	0.048
	GO_GLOMERULUS_DEVELOPMENT	0.69	2.27	< 0.0001	0.046
	HP_HEMOPTYSIS	0.69	2.17	< 0.0001	0.033
	GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE	0.58	2.16	< 0.0001	0.048
	GO_ENDOCARDIAL_CUSHION_DEVELOPMENT	0.68	2.16	< 0.0001	0.047
	GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING	0.6	2.16	< 0.0001	0.047

GSEA gene set enrichment analysis, NES normalized enrichment score, NOM nominal, FDR false discovery rate

ISSN: 1475-2867