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Table 3 Relative pathways associated with the expression of CHRDL1 and SPARCL1 using GSEA

From: Low expression of CHRDL1 and SPARCL1 predicts poor prognosis of lung adenocarcinoma based on comprehensive analysis and immunohistochemical validation

Gene Name ES NES NOM
p-value
FDR
q-value
CHRDL1 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR − 0.55 − 1.93 < 0.0001 0.109
GO_CELL_CYCLE_CHECKPOINT − 0.51 − 1.93 0.006 0.107
GO_DNA_UNWINDING_INVOLVED_IN_DNA_REPLICATION − 0.81 − 1.93 < 0.0001 0.106
GO_EXONUCLEASE_ACTIVITY − 0.53 − 1.92 0.002 0.116
GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS − 0.53 − 1.92 0.006 0.114
GO_TELOMERE_ORGANIZATION − 0.54 − 1.91 0.002 0.114
GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE − 0.71 − 1.91 < 0.0001 0.114
GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION − 0.56 − 1.91 0.002 0.113
GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX − 0.73 − 1.91 0.002 0.112
GO_DNA_BIOSYNTHETIC_PROCESS − 0.47 − 1.91 0.002 0.112
SPARCL1 GO_ENDONUCLEASE_COMPLEX − 0.68 − 2.17 < 0.0001 0.047
GO_BASE_EXCISION_REPAIR − 0.67 − 2.11 0.002 0.048
GO_SPLICEOSOMAL_COMPLEX − 0.6 − 2.1 < 0.0001 0.031
GO_NCRNA_METABOLIC_PROCESS − 0.59 − 2.1 < 0.0001 0.048
GO_MITOTIC_SPINDLE_ORGANIZATION − 0.61 − 2.09 < 0.0001 0.048
GO_GLOMERULUS_DEVELOPMENT 0.69 2.27 < 0.0001 0.046
HP_HEMOPTYSIS 0.69 2.17 < 0.0001 0.033
GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE 0.58 2.16 < 0.0001 0.048
GO_ENDOCARDIAL_CUSHION_DEVELOPMENT 0.68 2.16 < 0.0001 0.047
GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING 0.6 2.16 < 0.0001 0.047
  1. GSEA gene set enrichment analysis, NES normalized enrichment score, NOM nominal, FDR false discovery rate