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Fig. 4 | Cancer Cell International

Fig. 4

From: Long noncoding RNA ILF3-AS1 aggravates papillary thyroid carcinoma progression via regulating the miR-4306/PLAGL2 axis

Fig. 4

PLAGL2 is a downstream target of miR-4306. a Venn diagram showed 3 common mRNA candidates for miR-4306 predicted by four databases. b, c RT-qPCR assay probed into the effects of miR-4306 mimics or sh/ILF3-AS1#1/2 on the expression of candidate mRNAs. d The expression level of PLAGL2 in PTC cells was identified by RT-qPCR. e Ago2-RIP assay demonstrated the enrichment of ILF3-AS1, miR-4306 and PLAGL2 in anti-Ago2 group or anti-IgG group. f The interaction between miR-4306 and PLAGL2 was proven by RNA pull down assay. g, h The predicted binding sites between miR-4306 and PLAGL2 was shown and verified by dual luciferase reporter assay. i Western blot analysis was conducted to detect the protein level of PLAGL2 after the overexpression or knockdown of miR-4306. *P < 0.05, **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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