Fig. 3

RAD51 associates with ovarian cancer. In UALCAN, 557 genes correlated with RAD51 in TCGA ovarian cancer. Enrichment analysis was performed using these 557 genes. a Gene Ontology pathways involved in DNA damage repair and drug responsiveness were shown. b KEGG pathways implicated in DNA damage repair and drug responsiveness were depicted. In NCBI, 209 genes interacted with RAD51. These 209 genes overlapped with the 557 genes correlated with RAD51, producing 36 overlapping genes. c Venn diagram of these 209 genes and the 557 genes correlated with RAD51 (Chi-squared test). d The protein–protein interaction network of RAD51 with the 36 overlapping genes was constructed, and interaction confidence was calculated. e Based on computation of similar target-to-disease connections and overall association scores, the targets related to RAD51 were examined in the Open Targets platform and the top 20 targets were depicted in detail