CircRNA_100290 promotes GC cell proliferation and invasion via the miR-29b-3p/ITGA11 axis and is regulated by EIF4A3

Table 3 Relevance analysis between expression of EIF4A3 and clinicopathological characteristics in GC patients from GEO database^a

Characteristics	N = 300	Expression of EIF4A3		χ2	P
Characteristics	N = 300	Low	High	χ2	P
Gender				5.513	0.019
Male	199	20 (10.1%)	179
Female	101	20 (19.8%)	81
Age (years)				7.887	0.005
≤ 63	148	28 (18.9%)	120
> 63	152	12 (7.9%)	140
Lauren’s types				22.73	0.000
Intestinal	146	7 (4.8%)	139
Diffuse	134	32 (23.9%)	102
Mixed	17	1 (5.9%)	16
Depth of invasion				8.897	0.012
T2	188	17 (9%)	171
T3	91	20 (22%)	71
T4	21	3 (14.3%)	18
Ln metastasis				1.114	0.291
N0	38	3 (7.9%)	35
N1 ~ N3	262	37 (15.3%)	225
Distant Metastasis				0.902	0.342
M0	273	38 (13.9%)	235
M1	27	2 (7.4%)	25
TNM Staging				8.916	0.030
I	31	1 (3.2%)	30
II	97	12 (12.4%)	85
III	95	20 (21.1%)	75
IV	77	7 (9.1%)	70
ACRG’s mol. types				34.989	0.000
MSI	68	1 (1.5%)	67
MSS/TP53⁻	107	8 (7.5%)	99
MSS/TP53⁺	79	14 (17.7%)	65
MSS/EMT	46	17 (37%)	29

Ln. Lymph node, ACRG Asian Cancer Research Group, mol. Molecular, MSI microsatellite instability, MSS Microsatellite stability, TP53⁻ TP53 inactive, TP53⁺ TP53 active, EMT epithelial-to-mesenchymal transition
^aGEO accession number: GSE62254

ISSN: 1475-2867