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Table 1 Leading OV candidates applied in clinical trials

From: Oncolytic virotherapy reverses the immunosuppressive tumor microenvironment and its potential in combination with immunotherapy

OV type Genome structure OV mutant Genetic modification Clinical application Administration approach
HSV-1 Double stranded DNA T-Vec ICP34.5 and ICP47 deletion
GM-CSF insertion
Melanoma, sarcoma, head and neck cancer, breast cancer, colorectal cancer, pancreatic cancer Intratumoral
HF10 UL43, UL49.5, UL55, UL56, and LAT deletion Melanoma, breast cancer, pancreatic cancer Intratumoral
HSV1716 ICP34.5 mutation Late-stage pediatric cancers, melanoma, hepatocellular carcinoma, glioblastoma,mesothelioma, neuroblastoma Intratumoral, intravenous
Adenovirus Double stranded DNA ONYX-15 E1B55K deletion Pancreatic cancer, colorectal cancer, head and neck cancer, ovarian cancer Intratumoral
H101 E1B55K & partial E3 deletion, Head and neck cancer Intratumoral
LOAd703 E1ACR2 deletion,
E2F-binding sites insertion
TMZ-CD40L & 4-1BBL insertion
Pancreatic cancer, melanoma Intratumoral
VCN-01 E1ACR2 deletion,
E2F-binding sites insertion,
PH20 hyaluronidase insertion,
RGD insertion in the fibre knob
Head and neck cancer, retinoblastoma, pancreatic cancer Intratumoral,
intravenous, intravitrous
Telomelysin (OBP-301) hTERT insertion Solid tumors Intratumoral
ONCOS-102 GM-CSF insertion Peritoneal malignancies, prostate cancer Intratumoral
Vaccinia virus Double stranded DNA Pexa-Vec (JX-594) thymidine kinase mutation
GM-CSF, lacZ insertion
Hepatocellular carcinoma, colorectal cancer, solid tumors Intratumoral, intravenous
GL-ONC1 Ruc-GFP, lacZ, gusA insertion Head and neck cancer, ovarian cancer Intravenous
Parvovirus Single stranded DNA H-1PV
/ Glioblastoma, pancreatic cancer Intratumoral, intravenous
Reovirus Double stranded RNA Reolysin®
/ Melanoma, breast cancer, prostate cancer, ovarian cancer, multiple myeloma, pancreatic cancer, colorectal cancer, non-small cell lung carcinoma Intravenous
Measles virus Single stranded RNA MV-NIS Sodium-iodide symporter insertion Multiple myeloma Intravenous
Coxsackie virus Single stranded RNA CAVATAK / Melanoma, breast cancer, prostate cancer, bladder cancer, non-small cell lung carcinoma Intratumoral