Fig. 6

Analysis of correlation among HSP70s, gene mutation and functional enrichment analysis of HSP70. A HSPA1A and HSPA1B, HSPA4 and HSPA8, HSPA4 and HSPA9, HSPA6 and HSPA1A, HSPA6 and HSPA1B, HSPA13 and HSPA14 had very significant correlation (correlation coefficient > 0.3). B The mutation rate of HSP70s gene was 58.55%. the mutation rates of HSPA1L, HSPA4, HSPA6 and HSPA9 are all higher than 10%, mRNA High and Amplification are the most common mutation types. C Thirty neighbor genes significantly related to HSP70s were found through STRING database. D Using Cytoscape 3.7.1 to display PPI results through inter-gene connectivity, we found that HSPA8 and HSPA5 played a central role in this network. Then, through the analysis, annotation, visualization and comprehensive discovery of GO (E) and KEGG (F) analysis in DAVID database