Skip to main content
Fig. 6 | Cancer Cell International

Fig. 6

From: Vesicle transporter GOLT1B mediates the cell membrane localization of DVL2 and PD-L2 and promotes colorectal cancer metastasis

Fig. 6

GOLT1B regulates the expression and membrane translation of PD-L2. a The correlation between GOLT1B and immuno-infiltrating cells in CRC from TIMER database. b Co-culture of HCT116 and Jurkat cell showed that GOLT1B overexpression in cancer cells could induce Jurkat cells apoptosis and c inhibit the IFN-γ level in Jurkat cell. d The correlation between PD-L2 and GOLT1B in CRC from GEPIA2 database. e GOLT1B knockdown or overexpression could decrease and increase PD-L2 level in CRC cells, respectively. f The cell membrane and cytoplasm separation experiment showed that GOLT1B could upregulate the PD-L2 level on the cell membrane. g The CO-IP experiment confirmed the interaction between GOLT1B and PD-L2

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us