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Fig. 6 | Cancer Cell International

Fig. 6

From: LncRNA WDFY3-AS2 promotes cisplatin resistance and the cancer stem cell in ovarian cancer by regulating hsa-miR-139-5p/SDC4 axis

Fig. 6

LncRNA WDFY3-AS2 promoted the cisplatin-resistant in OC A2780-DDP cells by up-regulating SDC4 by sponging miR-139-5p. A, B mRNA and protein levels of SDC4 in si-WDFY3-AS2 transfected cells with co-transfection of miR-139-5p inhibitor or pcDNA-SDC4 (SDC4) as measured via qRT-PCR and western blot. C, CCK8 results of the cell viability of transfected A2780-DDP cells. D OC A2780-DDP cells apoptosis after co-transfection and treatment of cisplatin as assessed via flow cytometry. E, F Transwell assay showed that the invasive and migration activity in A2780-DDP cells (100 μm). ***P < 0.001 vs. control, ###P < 0.001 vs. si-WDFY3-AS2 + inhibitor NC, &&&P < 0.001 vs. si-WDFY3-AS2 + pcDNA-NC

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Cancer Cell International

ISSN: 1475-2867

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