A novel strategy to identify candidate diagnostic and prognostic biomarkers for gastric cancer

Table 4 Correlation between serum level of the three biomarkers and clinicopathological characteristics in GC patients

Characteristics	AGT level			SERPINH1 level			MMP7 level			Score 1 level			Score 2 level
Characteristics	Low (n = 66)	High (n = 66)	P-value	Low (n = 66)	High (n = 66)	P-value	Low (n = 66)	High (n = 66)	P-value	Low (n = 66)	High (n = 66)	P-value	Low (n = 66)	High (n = 66)	P-value
Gender
Male	45	45	1.00	49	41	0.135	47	43	0.455	49	41	0.135	51	38	0.196
Female	21	21		17	25		19	23		17	25		19	23
Age (years)
≤ 65	37	42	0.375	41	38	0.594	40	39	0.859	41	38	0.594	42	36	0.909
> 65	29	24		25	28		26	27		25	28		28	25
Tumor size (cm)
≤ 4	47	30	0.003	42	35	0.217	46	31	0.008	42	35	0.217	50	27	0.002
> 4	19	36		24	31		20	35		24	31		20	34
Tumor invasion
T1–T2	26	15	0.039	27	14	0.014	27	14	0.014	27	14	0.014	30	11	0.002
T3–T4	40	51		39	52		39	52		39	52		40	50
Lymph node invasion
Negative	27	22	0.368	27	22	0.368	27	22	0.368	27	22	0.368	30	19	0.167
Positive	39	44		39	44		39	44		39	44		40	42
Metastasis
Negative	57	54	0.475	58	53	0.234	59	52	0.096	58	53	0.234	63	47	0.044
Positive	9	12		8	13		7	14		8	13		7	14
TNM stage
I–II	38	24	0.015	40	22	0.002	38	24	0.015	40	22	0.002	42	20	0.002
III–IV	28	42		26	44		28	42		26	44		28	41

Score 1 = (0.180 × concentration of AGT) + (0.544 × concentration of SERPINH1) + (0.135 × concentration of MMP7), patients were divided into a high-risk group and a low-risk group according to the median of score 1
Score 2, two or more of the three proteins are high-expressed, the patients were divided into a high-risk group; otherwise, the patients were divided into a low-risk group

ISSN: 1475-2867