RSF1 in cancer: interactions and functions

Table 1 Function, RSF1 binding domain and SNF2H’s effects on function of different protein level of RSF1 with different RSF1 binding protein

The protein level of RSF1	RSF1 binding protein	Function	RSF1 binding domain	SNF2H’s effects on function
Normal	H2Aub	Oncogene transcription suppression	?	Yes
Normal	HDAC1	Protecting centromeric cohesion	aa 982–1441	Yes
Normal	CENP-A	Maintaining accurate chromosome segregation	?	Yes
Normal	PLK1	Maintaining accurate chromosome arrangment	aa 982–1441	?
Normal	ATM	DNA HR repair	?	?
Normal	CENP-S	DNA HR repair	aa 1068–1440	?
High	ATM	Decreasing the upregulated protein level of RSF1 upon DNA damage	?	?
Normal	SNF2H	Maintaining the protein homeostasis of RSF1	?	Yes
Normal	SNF2H	Stabilizing SNF2H in nucleus	aa 1–973	Yes
High	SNF2H	Promoting tumor growth	aa 1–973	Yes
High	SNF2H	Scrambling SNF2H from other remodeller complexes to RSF remodeller complex	?	Yes
High	BubR1	Inhibiting metaphase-to-anaphase mitotic checkpoint	?	?
High	HB_X	Inhibiting metaphase-to-anaphase mitotic checkpoint	?	?
High	Cyclin E1	Promoting tumorigenesis only in TP53^mut background	aa 1–441	?
High	CBP	Activating NF-κB induced transcription to increase chemoresistance	?	Yes
High	NF-κB	Activating NF-κB induced transcription to increase chemoresistance	?	Yes

ISSN: 1475-2867