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Table 1 Function, RSF1 binding domain and SNF2H’s effects on function of different protein level of RSF1 with different RSF1 binding protein

From: RSF1 in cancer: interactions and functions

The protein level of RSF1 RSF1 binding protein Function RSF1 binding domain SNF2H’s effects on function
Normal H2Aub Oncogene transcription suppression ? Yes
Normal HDAC1 Protecting centromeric cohesion aa 982–1441 Yes
Normal CENP-A Maintaining accurate chromosome segregation ? Yes
Normal PLK1 Maintaining accurate chromosome arrangment aa 982–1441 ?
Normal ATM DNA HR repair ? ?
Normal CENP-S DNA HR repair aa 1068–1440 ?
High ATM Decreasing the upregulated protein level of RSF1 upon DNA damage ? ?
Normal SNF2H Maintaining the protein homeostasis of RSF1 ? Yes
Normal SNF2H Stabilizing SNF2H in nucleus aa 1–973 Yes
High SNF2H Promoting tumor growth aa 1–973 Yes
High SNF2H Scrambling SNF2H from other remodeller complexes to RSF remodeller complex ? Yes
High BubR1 Inhibiting metaphase-to-anaphase mitotic checkpoint ? ?
High HBX Inhibiting metaphase-to-anaphase mitotic checkpoint ? ?
High Cyclin E1 Promoting tumorigenesis only in TP53mut background aa 1–441 ?
High CBP Activating NF-κB induced transcription to increase chemoresistance ? Yes
High NF-κB Activating NF-κB induced transcription to increase chemoresistance ? Yes