Fig. 4

Metabolite differences based on histological subtype. A Absolute total amino acid concentration. Total amino acid concentration in high-grade serous ovarian carcinoma (HGSOC) and non-HGSOC was compared by Welch’s t-test, regardless of whether the sample was primary cancer (PC) or omental metastatic cancer (OMC). B The proportions of amino acids. The top 10 amino acids are shown, and the percentage of glutamine in HGSOC and non-HGSOC was compared by Welch’s t-test. C Schema of glutathione metabolism. Glutathione has two forms: a reduced form (GSH) and an oxidized disulfide form (GSSG). D Absolute GSH and GSSG concentrations. The GSH concentration was compared in HGSOC and non-HGSOC by Welch’s t-test. E Schema of polyamine metabolism. F Absolute polyamine concentration. The concentration of polyamines was compared in HGSOC and non-HGSOC by Welch’s t-test