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Fig. 5 | Cancer Cell International

Fig. 5

From: Circ_0001721 enhances doxorubicin resistance and promotes tumorigenesis in osteosarcoma through miR-758/TCF4 axis

Fig. 5

TCF4 was a target of miR-758. A The predicted binding sites of miR-758 and TCF4 3’UTR were displayed. B, C Dual-luciferase reporter assay was performed to validate the relationship between miR-758 and TCF4. D The expression of TCF4 was tested in Chemosensitive and Chemoresistant OS patients by western blot. E The protein level of TCF4 was detected in KHOS, KHOS/DXR, MG63 and MG63/DXR cells. F, G KHOS/DXR and MG63/DXR cells were introduced with miR-NC, miR-758, pcDNA or circ_0001721, and TCF4 expression was measured using western blot. *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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