Fig. 5

let-7 g attenuates the growth, migration, and invasion of ovarian cancer cells by regulating the MEST/ATGL axis. HO8910 and SKOV3cells were transfected with let-7 g mimic, oe-MEST or both. A Expression levels of let-7 g, MEST and ATGL in HO8910 cells determined by RT-qPCR. B Expression of let-7 g, MEST, and ATGL in SKOV3 cells determined by RT-qPCR. C Apoptosis of HO8910 and SKOV3 cells tested by flow cytometry. D Migration and invasion of HO8910 cells determined by Transwell assay. E Migration and invasion of SKOV3 cells determined by Transwell assay. *p < 0.05 vs. the NC-mimic + oe-NC group. #p < 0.05 vs. the let-7 g-mimic + oe-NC group. Measurement data were depicted as mean ± standard deviation, and assessed by one-way ANOVA followed by Tukey's post hoc test. All cell experiments were performed 3 times independently