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Fig. 5 | Cancer Cell International

Fig. 5

From: ARHGAP10 inhibits the epithelial–mesenchymal transition of non-small cell lung cancer by inactivating PI3K/Akt/GSK3β signaling pathway

Fig. 5

ARHGAP10 suppressed EMT in NSCLC cells by PI3K/Akt/GSK3β signaling. a Western blot detected the essential components of PI3K/Akt/GSK3β signaling pathway in A549 and NCI-H1299 cells. b Western blot was performed to explore EMT biomarkers expression in A549 and NCI-H1299 cells infected with ARHGAP10 virus or empty vector virus and treated with IGF-1 (100 ng/mL) for 24 h. c, d IGF-1 reversed the biological effects of ARHGAP10 on cell proliferation and invasion capabilities in A549 and NCI-H1299 cells. (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001)

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Cancer Cell International

ISSN: 1475-2867

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