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Fig. 4 | Cancer Cell International

Fig. 4

From: Downregulation of Tim-1 inhibits the proliferation, migration and invasion of glioblastoma cells via the miR-133a/TGFBR1 axis and the restriction of Wnt/β-catenin pathway

Fig. 4

Tim-1 regulated the expression of miR-133a. A miR-133a expression was significantly increased in U87 and U251 cell lines after Tim-1 knockdown (n = 3); B miR-133a and TGFBR1 mRNA level in normal brain tissues (n = 15) and glioblastoma tissues (n = 76) were detected using qRT-PCR; C Pearson-Correlation analysis of miR-133a and TGFBR1 in human glioblastoma tissues; D Construction of Wt and Mut vectors of TGFBR1-3’UTR; N. The luciferase activity U87 and U251 cells co-transfected with miR-133a mimic or miR NC and Wt-TGFBR1 or Mut-TGFBR1 (n = 3). Data were expressed as mean ± standard deviation, and t-test was used for comparisons between two groups. One-way ANOVA was used for comparisons between multiple groups, comparison between two groups are followed by t test with Bonferroni correction

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Cancer Cell International

ISSN: 1475-2867

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