Fig. 8

The function of LRRK2 in ccRCC tumor cell lines and protein–protein interaction of LRRK2. a Western blotting for LRRK2 expression in stable knockdown ccRCC tumor cell lines, Caki-1 and A498 cells were stably infected with lentiviral shRNA targeting LRRK2 (sh-L) or with a nontargeting control shRNA (Lv-Con). Values are expressed as mean ± SEM (n = 3). Within each group, values significantly different from control (Con) (p < 0.05) are indicated with an asterisk or pound key; b the proliferation ability of stable knockdown Caki-1 was uncovered by CCK8 assay; c the proliferation ability of stable knockdown A498 was uncovered by CCK8 assay; d the protein–protein interaction network of LRRK2 by STRING database; e correlation between LRRK2 and EGFR in ccRCC using the Gene Expression Profiling Interactive Analysis (GEPIA) database