Fig. 3

 A summary of quercetin roles in osteosarcoma which include inducing apoptosis and suppressing proliferation as well as inhibiting migration and invasion. Furthermore, quercetin is shown to be effective in overcoming drug-resistance in osteosarcoma cells. To exert its anti-tumor roles, quercetin affects several molecular and cellular signaling pathways, such as VEGF, MMPs, caspases, AKT, and KRAS. Downward arrows represent downregulation or reduction. Upward arrows shows upregulation or increase