Table 1 Univariate and multivariate Cox regression analysis of the risk score
Characteristics | Univariate Cox analysis | Multivariate Cox analysis | ||
|---|---|---|---|---|
HR (95%CI) | P-value | HR (95%CI) | P-value | |
GSE143985 | ||||
 Stage (III vs II) | 4.058 (1.272–12.943) | 0.018 | 6.876 (1.276–37.041) | 0.025 |
 ACT (Y vs N) | 2.144 (0.743–6.186) | 0.158 | 0.989 (0.210–4.649) | 0.989 |
 TP53 (Mut vs Wt) | 0.400 (0.134–1.195) | 0.101 | 1.058 (0.270–4.152) | 0.935 |
 KRAS (Mut vs Wt) | 3.182 (1.065–9.510) | 0.038 | 2.289 (0.571–9.185) | 0.243 |
 Risk score | 4.296 (2.612–7.065) |  < 0.001 | 5.128 (2.662–9.880) |  < 0.001 |
GSE17536 | ||||
 Stage (III vs II) | 1.964 (0.941–4.099) | 0.072 | 0.967 (0.402–2.326) | 0.142 |
 Age (> 60 vs ≤ 60) | 0.482 (0.238–0.978) | 0.043 | 0.728 (0.308–1.721) | 0.009 |
 Sex (Male vs Female) | 1.138 (0.562–2.304) | 0.720 | 3.155 (1.196–8.321) | 0.370 |
 Risk score | 2.354 (1.662–3.334) |  < 0.001 | 2.527 (1.720–3.705) |  < 0.001 |
GSE29621 | ||||
 Stage (III vs II) | 2.785 (0.525–14.774) | 0.229 | 0.886 (0.093–8.072) | 0.900 |
 Age (> 60 vs ≤ 60) | 1.083 (0.242–4.849) | 0.917 | 0.888 (0.095–8.253) | 0.917 |
 ACT (Y vs N) | 1.628 (0.311–8.531) | 0.564 | 5.698 (0.323–100.67) | 0.235 |
 Risk score | 3.934 (1.622–9.539) | 0.002 | 5.150 (1.558–17.030) | 0.007 |
GSE92921 | ||||
 Stage (III vs II) | 6.229 (1.140–34.035) | 0.035 | 3.706 (0.585–23.486) | 0.164 |
 TP53 (Mut vs Wt) | 1.453 (0.266–7.932) | 0.666 | 1.050 (0.165–6.677) | 0.959 |
 KRAS (Mut vs Wt) | 3.217 (0.589–17.580) | 0.177 | 2.720 (0.280–26.448) | 0.389 |
 Risk score | 7.080 (2.011–24.924) | 0.002 | 6.311 (1.691–23.562) | 0.006 |