Skip to main content

Table 1 Univariate and multivariate Cox regression analysis of the risk score

From: Development and clinical validation of a novel six-gene signature for accurately predicting the recurrence risk of patients with stage II/III colorectal cancer

Characteristics Univariate Cox analysis Multivariate Cox analysis
HR (95%CI) P-value HR (95%CI) P-value
GSE143985
 Stage (III vs II) 4.058 (1.272–12.943) 0.018 6.876 (1.276–37.041) 0.025
 ACT (Y vs N) 2.144 (0.743–6.186) 0.158 0.989 (0.210–4.649) 0.989
 TP53 (Mut vs Wt) 0.400 (0.134–1.195) 0.101 1.058 (0.270–4.152) 0.935
 KRAS (Mut vs Wt) 3.182 (1.065–9.510) 0.038 2.289 (0.571–9.185) 0.243
 Risk score 4.296 (2.612–7.065)  < 0.001 5.128 (2.662–9.880)  < 0.001
GSE17536
 Stage (III vs II) 1.964 (0.941–4.099) 0.072 0.967 (0.402–2.326) 0.142
 Age (> 60 vs ≤ 60) 0.482 (0.238–0.978) 0.043 0.728 (0.308–1.721) 0.009
 Sex (Male vs Female) 1.138 (0.562–2.304) 0.720 3.155 (1.196–8.321) 0.370
 Risk score 2.354 (1.662–3.334)  < 0.001 2.527 (1.720–3.705)  < 0.001
GSE29621
 Stage (III vs II) 2.785 (0.525–14.774) 0.229 0.886 (0.093–8.072) 0.900
 Age (> 60 vs ≤ 60) 1.083 (0.242–4.849) 0.917 0.888 (0.095–8.253) 0.917
 ACT (Y vs N) 1.628 (0.311–8.531) 0.564 5.698 (0.323–100.67) 0.235
 Risk score 3.934 (1.622–9.539) 0.002 5.150 (1.558–17.030) 0.007
GSE92921
 Stage (III vs II) 6.229 (1.140–34.035) 0.035 3.706 (0.585–23.486) 0.164
 TP53 (Mut vs Wt) 1.453 (0.266–7.932) 0.666 1.050 (0.165–6.677) 0.959
 KRAS (Mut vs Wt) 3.217 (0.589–17.580) 0.177 2.720 (0.280–26.448) 0.389
 Risk score 7.080 (2.011–24.924) 0.002 6.311 (1.691–23.562) 0.006