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Table 1 The differentially expressed proteins between EBV-positive and negative GC

From: Identification of differential proteomics in Epstein-Barr virus-associated gastric cancer and related functional analysis

Genes Protein description FC (abs) P value Regulation
GBP5 Guanylate-binding protein 5 3.45 0.028 Up
C5AR1 C5a anaphylatoxin chemotactic receptor 1 3.39 0.038 Up
THRAP3 Thyroid hormone receptor-associated protein 3 3.25 0.002 Up
P3H3 Prolyl 3-hydroxylase 3 3.10 0.035 Up
MDK Midkine 3.07 0.042 Up
ALOX5AP Arachidonate 5-lipoxygenase-activating protein 2.84 0.048 Up
BPI Bactericidal permeability-increasing protein 2.69 0.025 Up
HLA-DRB1 HLA class II histocompatibility antigen, DRB1-12 beta chain 2.56 0.015 Up
PPL Periplakin 2.49 0.027 Up
ISLR Immunoglobulin superfamily containing leucine-rich repeat protein 2.31 0.047 Up
APOL2 Apolipoprotein L2 2.29 0.009 Up
HCK Tyrosine-protein kinase HCK 2.21 0.020 Up
AKAP2 A-kinase anchor protein 2 2.17 0.026 Up
ITGA11 Integrin alpha-11 2.14 0.024 Up
ITGB2 Integrin beta-2 2.13 0.025 Up
COQ6 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial 2.09 0.039 Up
DENND1C DENN domain-containing protein 1C 2.06 0.002 Up
RAB31 Ras-related protein Rab-31 2.05 0.041 Up
CYBA Cytochrome b-245 light chain 2.02 0.001 Up
FCGR3A Low affinity immunoglobulin gamma Fc region receptor III-A 1.94 0.044 Up
CYBB Cytochrome b-245 heavy chain 1.90 0.007 Up
KEAP1 Kelch-like ECH-associated protein 1 1.88 0.003 Up
KALRN Kalirin 1.86  < 0.001 Up
GBP1 Guanylate-binding protein 1 1.85 0.020 Up
DPYD Dihydropyrimidine dehydrogenase [NADP( +)] 1.81 0.049 Up
TOR1B Torsin-1B 1.80 0.014 Up
CNN2 Calponin-2 1.78 0.041 Up
TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3 1.78 0.023 Up
TAP1 Antigen peptide transporter 1 1.76 0.037 Up
SRRM2 Serine/arginine repetitive matrix protein 2 1.75 0.026 Up
CD40 Tumor necrosis factor receptor superfamily member 5 1.74 0.036 Up
FUT8 Alpha-(1,6)-fucosyltransferase 1.71 0.037 Up
SCAF1 Splicing factor, arginine/serine-rich 19 1.69 0.044 Up
TLR3 Toll-like receptor 3 1.66 0.020 Up
GRN Granulins 1.65 0.029 Up
NSA2 Ribosome biogenesis protein NSA2 homolog 1.64 0.050 Up
CLASP1 CLIP-associating protein 1 1.61 0.033 Up
CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 1.61 0.023 Up
ATP6AP1 V-type proton ATPase subunit S1 1.60 0.022 Up
CARHSP1 Calcium-regulated heat-stable protein 1 1.60 0.037 Up
LPCAT2 Lysophosphatidylcholine acyltransferase 2 1.59 0.040 Up
GALNT2 Polypeptide N-acetylgalactosaminyltransferase 2 1.59 0.038 Up
COMMD10 COMM domain-containing protein 10 1.59 0.032 Up
ATP6V1D V-type proton ATPase subunit D 1.57 0.020 Up
LRRC40 Leucine-rich repeat-containing protein 40 1.54 0.011 Up
PREX1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein 1.53 0.029 Up
GBP2 Guanylate-binding protein 2 1.53 0.023 Up
PEBP1 Phosphatidylethanolamine-binding protein 1 1.51 0.016 Down
UBR5 E3 ubiquitin-protein ligase UBR5 1.51 0.049 Down
TXN2 Thioredoxin, mitochondrial 1.52 0.011 Down
ADD1 Alpha-adducin 1.52 0.019 Down
EPB41L1 Band 4.1-like protein 1 1.52 0.033 Down
IDI1 Isopentenyl-diphosphate Delta-isomerase 1 1.54 0.009 Down
EML2 Echinoderm microtubule-associated protein-like 2 1.55 0.035 Down
ATP1B1 Sodium/potassium-transporting ATPase subunit beta-1 1.55 0.035 Down
EIF4A2 Eukaryotic initiation factor 4A-II 1.56 0.004 Down
MRI1 Methylthioribose-1-phosphate isomerase 1.56 0.009 Down
CST3 Cystatin-C 1.56 0.035 Down
ABHD14B Protein ABHD14B 1.57 0.013 Down
ARFIP2 Arfaptin-2 1.58 0.021 Down
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 1.58 0.014 Down
PSMG4 Proteasome assembly chaperone 4 1.59 0.036 Down
ECSIT Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial 1.59 0.030 Down
RNMT mRNA cap guanine-N7 methyltransferase 1.59 0.019 Down
CD46 Membrane cofactor protein 1.61 0.022 Down
SUPV3L1 ATP-dependent RNA helicase SUPV3L1, mitochondrial 1.61 0.042 Down
DTD1 D-aminoacyl-tRNA deacylase 1 1.61 0.009 Down
FAM213A Redox-regulatory protein FAM213A 1.63 0.019 Down
C11orf54 Ester hydrolase C11orf54 1.63 0.049 Down
BCKDHB 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.64 0.012 Down
GFPT1 Glutamine–fructose-6-phosphate aminotransferase [isomerizing] 1 1.64 0.043 Down
EPB41L2 Band 4.1-like protein 2 1.64 0.035 Down
RAB6D/RAB6C Ras-related protein Rab-6D/Ras-related protein Rab-6C 1.66 0.025 Down
DAG1 Dystroglycan 1.66 0.018 Down
HEBP2 Heme-binding protein 2 1.67 0.039 Down
QDPR Dihydropteridine reductase 1.68 0.047 Down
UBE4B Ubiquitin conjugation factor E4 B 1.68 0.045 Down
NAXE NAD(P)H-hydrate epimerase 1.68 0.007 Down
GLRX5 Glutaredoxin-related protein 5, mitochondrial 1.70 0.006 Down
PPOX Protoporphyrinogen oxidase 1.70 0.012 Down
CHRAC1 Chromatin accessibility complex protein 1 1.71 0.048 Down
MPST 3-mercaptopyruvate sulfurtransferase 1.73 0.015 Down
COQ3 Ubiquinone biosynthesis O-methyltransferase, mitochondrial 1.73 0.015 Down
F13A1 Coagulation factor XIII A chain 1.74 0.033 Down
SGCD Delta-sarcoglycan 1.75 0.020 Down
NFU1 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial 1.75 0.016 Down
TXLNG Gamma-taxilin 1.76 0.010 Down
NRM Nurim 1.78 0.026 Down
ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 1.78 0.015 Down
TXNL4A Thioredoxin-like protein 4A 1.80 0.024 Down
F11R Junctional adhesion molecule A 1.80 0.009 Down
H2AFY2 Core histone macro-H2A.2 1.81 0.020 Down
SPRYD4 SPRY domain-containing protein 4 1.82 0.049 Down
RIDA 2-iminobutanoate/2-iminopropanoate deaminase 1.83 0.012 Down
MLYCD Malonyl-CoA decarboxylase, mitochondrial 1.85 0.007 Down
ACY1 Aminoacylase-1 1.87 0.001 Down
CDC5L Cell division cycle 5-like protein 1.88 0.018 Down
ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1.89 0.014 Down
DARS2 Aspartate–tRNA ligase, mitochondrial 1.94 0.014 Down
2-Mar Mitochondrial amidoxime reducing component 2 1.96 0.008 Down
CA1 Carbonic anhydrase 1 1.99 0.025 Down
BRK1 Protein BRICK1 2.00 0.005 Down
CAVIN2 Caveolae-associated protein 2 2.02 0.029 Down
SELENBP1 Methanethiol oxidase 2.03 0.037 Down
COQ8A Atypical kinase COQ8A, mitochondrial 2.04 0.030 Down
HBG1 Hemoglobin subunit gamma-1 2.07 0.021 Down
PFN2 Profilin-2 2.07  < 0.001 Down
ARHGEF10 Rho guanine nucleotide exchange factor 10 2.08 0.003 Down
GRIP2 Glutamate receptor-interacting protein 2 2.12 0.023 Down
SH3BGRL2 SH3 domain-binding glutamic acid-rich-like protein 2 2.14 0.034 Down
TMEM63A CSC1-like protein 1 2.18 0.048 Down
CRAT Carnitine O-acetyltransferase 2.18 0.003 Down
HBE1 Hemoglobin subunit epsilon 2.26 0.036 Down
IGKV2-24 Immunoglobulin kappa variable 2–24 2.28 0.023 Down
VWA5A von Willebrand factor A domain-containing protein 5A 2.36 0.012 Down
MAOB Amine oxidase [flavin-containing] B 2.37 0.009 Down
DEPTOR DEP domain-containing mTOR-interacting protein 2.39 0.013 Down
LTBP4 Latent-transforming growth factor beta-binding protein 4 2.40 0.029 Down
THADA Thyroid adenoma-associated protein 2.45 0.049 Down
ACSS1 Acetyl-coenzyme A synthetase 2-like, mitochondrial 2.45 0.023 Down
ASS1 Argininosuccinate synthase 2.47 0.013 Down
EPHB3 Ephrin type-B receptor 3 2.54 0.015 Down
ADH1B Alcohol dehydrogenase 1B 2.64 0.044 Down
HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 2.65 0.046 Down
SLC12A2 Solute carrier family 12 member 2 2.72 0.002 Down
PTGR1 Prostaglandin reductase 1 2.73 0.002 Down
PHGDH D-3-phosphoglycerate dehydrogenase 2.75 0.005 Down
LRRC1 Leucine-rich repeat-containing protein 1 2.75 0.011 Down
FAF1 FAS-associated factor 1 2.86 0.018 Down
OPLAH 5-oxoprolinase 2.87 0.003 Down
CKMT1A Creatine kinase U-type, mitochondrial 2.91 0.048 Down
CEP250 Centrosome-associated protein CEP250 3.19 0.004 Down
BCAM Basal cell adhesion molecule 3.55 0.029 Down
EPHB2 Ephrin type-B receptor 2 3.80 0.047 Down
MFAP4 Microfibril-associated glycoprotein 4 4.09 0.034 Down
AKR7A3 Aflatoxin B1 aldehyde reductase member 3 4.11 0.034 Down
TMEM168 Transmembrane protein 168 4.56 0.011 Down
  1. EBV Epstein-Barr virus, GC gastric cancer, FC (abs) absolute fold change