Cancer Cell International

Table 2 Relationship between pathological characteristics and PD-L1 and PD-1 expression in intrahepatic cholangiocarcinoma

From: Relationship between PD-L1 expression, CD8+ T-cell infiltration and prognosis in intrahepatic cholangiocarcinoma patients

	n	PD-L1 expression				PD-1 expression
	n	Cancerous cell (+)	p value	Stromal cells (+)	p value	Lymphocyte (+)	p value
Tumor size, cm			0.806		0.9		0.034
> 5 cm	33	3 (9.1%)		17 (51.5%)		6 (18.2%)
≤ 5 cm	36	5 (13.9%)		18 (50%)		15 (41.7%)
Tumor number			0.812		0.348		0.499
Single	54	6 (11.1%)		29 (53.7%)		18 (33.3%)
Multiple	15	2 (13.3%)		6 (40%)		3 (20%)
Gross types			0.186		0.348		0.22
MF	54	8 (14.8%)		29 (53.7%)		14 (25.9%)
Non-MF	15	0 (0)		6 (40%)		7 (46.7%)
Differentiation			0.043		0.308		0.408
Well		0 (0)		1 (2.8%)		1 (4.8%)
Moderately		5 (63%)		29 (82.9%)		19 (90.4%)
Poorly or undifferentiated		3 (37%)		5 (14.3%)		1 (4.8%)
CLC or cICC	14	3 (21.4%)	0.412	9 (64.3%)	0.256	3 (21.4%)	0.621
MVI	25	4 (16%)	0.638	0 (0)	0.199	4 (16%)	0.005
Neural invasion	69	8 (11.6%)	0.227	35 (50.7%)	0.988	21 (30.4%)	1.0
TNM stage			0.245		0.429		0.282
I	28	1 (3.6%)		6 (21.4%)		8 (28.6%)
II	25	5 (20%)		13 (52%)		6 (24%)
III	5	1 (20%)		2 (40%)		1 (20%)
IV	11	1 (9.1%)		6 (54.5%)		6 (54.5%)
Breakthrough the liver	12	1 (8.3%)	0.698	6 (50%)	0.956	3 (25%)	0.916
Grade of inflammation			0.961		0.504		0.853
G0,G1or G2	60	7 (11.7%)		29 (48.3%)		19 (31.7%)
G3 or G4	9	1 (11.1%)		6 (66.7%)		2 (22.2%)
Fibrosis/cirrhosis			0.012		0.77		0.686
S0,S1 or S2	59	4 (6.78%)		29 (49.2%)		19 (32.2%)
(S3 or S4)	10	4 (40%)		6 (60%)		2 (20%)
CD8 density/Hp
CD8+ TIL ≥ 40	4	4 (100%)	< 0.0001	4 (100%)		1 (25%)
CD8+ NIL ≥ 40	19	6 (31.6%)	< 0.0001	13 (68.4%)		8 (42.1%)

MF mass-forming, CLC Cholangiolocellular Carcinoma, cICCconventional Intrahepatic Cholangiocarcinoma, MVI microvascular invasion

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