Fig. 2
From: CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis
The influence of circFBXL5 on the 5-FU resistance in breast cancer cells. A circFBXL5 level in 5-FU-resistant and sensitive MDA-MB-231 and MDA-MB-453 cells. B circFBXL5 expression in MDA-MB-231/5-FU and MDA-MB-453/5-FU cells with transfection of si-circFBXL5 or si-con. C, D Cell viability and IC50 of 5-FU in cells with transfection of si-circFBXL5 or si-con after exposure to various doses of 5-FU for 72 h. E, F Cell migration and invasion in cells with transfection of si-circFBXL5 or si-con. Bar: 50 μm. G Cell apoptosis in cells with transfection of si-circFBXL5 or si-con. Mock: non-transfected group. *P < 0.05