Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Table 1 List of genistein modulated miRNA and their targets in different cancers

Cancers	miRNAs	Expression	Targets	Refs.
Breast cancer	miR-155	Down-regulated	FOXO3, PTEN, casein kinase, p27	[51]
Breast cancer	miR-23b	Up-regulated	PAK2	[52, 53]
Prostate cancer	miR-151	Down-regulated	CASZ1, IL1RAPL1, SOX17, N4BP1 and ARHGDIA	[54]
	miR-34a	Up-regulated	HOTAIR	[55]
	miR-574-3p	Up-regulated	RAC1, EGFR, EP300	[56]
	miR-1296	Down-regulated	minichromosome maintenance gene family	[57]
	miR-200 miR-141	Up-regulated	DNMT3A and TET1/TET3	[58]
	miR-1260b	Up-regulated	sFRP1 and Smad4	[59]
Colorectal cancer	miR-95	Down-regulated	Akt, SGK1	[60]
Pancreatic cancer	miR-223	Down-regulated	Fbw7	[61]
	miR-34a	Up-regulated	Notch-1	[62]
	miR-27a	Down-regulated	Sprouty2
Uveal melanoma	miR-27a	Down-regulated	ZBTB10	[63]
Ovarian cancer	miR-27a	Down-regulated	Sprouty2	[64]
Lung cancer	miR-27a	Up-regulated	MET	[65]
Lung cancer	miR-873-5p	Down-regulated	FOXM1	[66]

ISSN: 1475-2867