Fig. 4
From: miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5
miR-198 regulates cell migration and invasion. A A498 and ACHN cells were transfected with the scrambled mimic of miR-198, wild-type miR-198, and miR-198 + FLAG-BIRC5; after 36 h, cells were analyzed using the wound healing assay, and the results were determined at 0 and 24 h. B Statistical analysis of the cell migration ratio of A498 cells using Image J. ****P < 0.0001. C Statistical analysis of the cell migration ration of ACHN cells. ****P < 0.0001. D Transwell assay. A498 and ACHN cells were treated as described in (A), after 36 h, the cells were digested, resuspended, and cultured in a Matrigel-coated transwell chamber and tested for invasion after 12 h. E Statistical analysis of cell invasion of A498 cells using Image J. ****P < 0.0001. F Statistical analysis of cell invasion of ACHN cells. ****P < 0.0001