Fig. 3From: Aurora kinase A (AURKA) promotes the progression and imatinib resistance of advanced gastrointestinal stromal tumorsExpression patterns of AURKA in GISTs and other human malignancies. AÂ Immunohistochemical (IHC) staining of GIST specimens. I: strong staining, II: intermediate staining, III: weak staining. BÂ IHC scores of AURKA varied across different GIST risk groups, with high-risk GISTs showing the highest expression of AURKA. CÂ Patients with elevated AURKA expression levels exhibited poorer DFS than those with low AURKA expression levels. DÂ The Oncomine and GEPIA databases showed a significant upregulation of AURKA expression in most human malignancies compared to normal tissuesBack to article page