Fig. 4

Expression profiles of AURKA in different GIST cohorts. A Based on data from the GSE136755 dataset, AURKA expression was significantly associated with tumor location, stage and risk stratification, while there was no obvious correlation between AURKA expression and imatinib-related gene mutations. B Analysis of the raw data from Lagarde et al. (PMID: 22167411) revealed that AURKA expression was significantly associated with risk stratification and imatinib-related gene mutations. There is also an obvious correlation between AURKA expression and clinical outcomes, such as local recurrence and metastasis. There were no significant differences in AURKA expression levels among gastric, nongastric and parenteral GISTs