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Fig. 4 | Cancer Cell International

Fig. 4

From: Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling

Fig. 4

Regulation of miR-146b-5p and ITGA2 expression in bladder cancer cells by lnc-STYK1-2. A Hierarchical clustering of mRNAs differentially expressed in 5637 and T24 cells transfected with lnc-STYK1-2 siRNAs. The mRNA profile in bladder cancer cells was determined by RNA sequencing. Higher and lower mRNA expressions are presented in red and blue colors, respectively. B Functional categorization of differentially expressed mRNAs induced by lnc-STYK1-2 siRNAs based on KEGG signaling pathways. C The lncRNA–microRNA–mRNA interaction networks were established based on lnc-STYK1-2 and differentially expressed mRNAs in (A) through the Cytoscape software. D Expressional alterations in Fas, NR5A2, and ITGA2 genes in bladder cancer cells with silencing of lnc-STYK1-2. The relative gene expression was detected via qRT-PCR. E Increased expression of miR-146b-5p in T24 and 5637 cells caused by lnc-STYK1-2 silencing. NC: negative control; STYK1: serine/threonine/tyrosine kinase 1; NR5A2: nuclear receptor 5A; ITGA2: integrin α2; **P < 0.01; ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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