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Table 5 Distribution frequency of WISP1polymorphisms in controls and gastric cancer patients stratified by cell differentiation

From: Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Variables

Moderate and poor differentiation

Well differentiation

Controls (N = 227)

Cancer (N = 168)

AOR (95% CI)

P

Cancer (N = 36)

AOR (95% CI)

P

rs2929973

 Co-dominant TT

102(44.9)

81(48.2)

1.00ref

 

19(52.8)

1.00ref

 

 TG

91(40.1)

72(42.9)

1.03(0.65–1.62)

0.912

13(36.1)

0.86(0.36–2.07)

0.730

 GG

34(15.0)

15(8.9)

0.60(0.29–1.21)

0.151

4(11.1)

0.96(0.27–3.39)

0.953

 Dominant TT

102(44.9)

81(48.2)

1.00ref

 

19(52.8)

1.00ref

 

 TG + GG

125(55.1)

87(51.8)

0.90(0.58–1.37)

0.612

17(47.2)

0.88(0.39–1.99)

0.766

 Recessive TT + TG

193(85.0)

153(91.1)

1.00ref

 

32(88.9)

1.00ref

 

 GG

34(15.0)

15(8.9)

0.59(0.30–1.14)

0.117

4(11.1)

1.03(0.31–3.42)

0.960

rs7843546

 Co-dominant CC

36(15.9)

34(20.2)

1.00ref

 

7(19.4)

1.00ref

 

 CT

119(52.4)

86(51.2)

0.79(0.45–1.41)

0.426

23(63.9)

1.14(0.40–3.24)

0.801

 TT

72(31.7)

48(28.6)

0.71(0.38–1.31)

0.272

6(16.7)

0.42(0.11–1.56)

0.197

 Dominant CC

36(15.9)

34(20.2)

1.00ref

 

7(19.4)

1.00ref

 

 CT + TT

191(84.1)

134(79.8)

0.77(0.45–1.32)

0.333

29(80.6)

0.87(0.31–2.39)

0.782

 Recessive CT + CC

155(68.3)

120(71.4)

1.00ref

 

30(83.3)

1.00ref

 

 TT

72(31.7)

48(28.6)

0.86(0.54–1.35)

0.504

6(16.7)

0.38(0.14–1.07)

0.067

rs10956697

 Co-dominant CC

86(37.9)

79(47.0)

1.00ref

 

16(44.4)

1.00ref

 

 AC

114(50.2)

70(41.7)

0.73(0.46–1.14)

0.165

18(50.0)

0.90(0.39–2.04)

0.792

 AA

27(11.9)

19(11.3)

0.96(0.47–1.93)

0.902

2(5.6)

0.67(0.13–3.55)

0.636

 Dominant CC

86(37.9)

79(47.0)

1.00ref

 

16(44.4)

1.00ref

 

 AC + AA

141(62.1)

89(53.0)

0.76(0.49–1.16)

0.201

20(55.6)

0.86(0.39–1.93)

0.719

 Recessive CC + AC

200(88.1)

149(88.7)

1.00ref

 

34(94.4)

1.00ref

 

 AA

27(11.9)

19(11.3)

1.12(0.58–2.17)

0.739

2(5.6)

0.71(0.14–3.55)

0.677

  1. ref reference; AOR Adjusted odds ratio; 95% CI 95% confidence interval; adjusted for gender, age, BMI, ethnicity, smoking and drinking alcohol