Fig. 1From: Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cellsOrigins and functions of CAFs. The main origin of CAFs include epithelial cells, mesenchymal stem cells, mesothelial cells, normal fibroblasts, cancer cells, adipocytes and so on. The influence of CAFs on tumor cells includes various aspects like drug resistance, tumor proliferation, metastasis, invasion, migration, immunomodulation, and angiogenesisBack to article page