Fig. 2

Glutamine metabolism between CAFs and cancer cells. CAFs can provide cancer cells with Lac, Gln and other nutrients into TCA cycle and urea cycle, and then promote the growth and development of tumor cells.The black pointed arrow heads indicate material transportation. The blue blunt arrowheads indicate inhibitory interactions. Arg ariginine, α-KG α-Ketoglutaric acid, Cit citrate, Lac lactose, Glc glucose, Glu glutamate, GSH glutathione, Orn ornithine, PYR pyruvate