Fig. 6

Remodelin inhibited the growth of HNSCC in the PDX model. a, b Nude mice were used for PDX model construction, Remodelin (100 mg/kg) was given daily by intragastric administration in the treatment group, and vehicle was given as a control. Tumour volume was recorded every 3–5 days, and the mice were sacrificed after intragastric administration for 4 weeks. The results indicated that HNSCC could be inhibited by Remodelin and that the body weights of mice were not affected (T test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). c, d Images of mice after Remodelin administration for 4 weeks. Tumour weight was decreased in the treatment group (T test, *P < 0.05). e HE and IHC staining of tumours from patients. NAT10 and Ki-67 were highly expressed. f HE and IHC staining of tumours from the PDX model without Remodelin administration. NAT10 and Ki-67 were highly expressed. g HE and IHC staining of tumours from the PDX model with Remodelin administration, lower expression of Ki-67 was observed