Table 3 Summary of the subgroup analyses of the association between OS and clinicopathological features in PC
Multivariate analysis | Univariate analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Included studies | HR (95% CI) | P value | I2 (%) | Effect model | Included studies | HR (95% CI) | P value | I2 (%) | Effect model |
Gender | 23 | 0.01 (− 0.14, 0.17) | 0.868 | 0.0% | Fixed | 10 | 0.04 (− 0.07, 0.16) | 0.344 | 8.5% | Fixed |
Distance metastasis | 20 | 0.08 (0.02, 0.13) | 0.000 | 74.7% | Random | 1 | 0.02 (− 0.53, 0.57) | 0.000 | 0% | – |
Node metastasis | 29 | 0.20 (0.12, 0.28) | 0.000 | 65.9% | Random | 5 | − 0.12 (− 0.34, 0.11) | 0.000 | 83.0% | Random |
Differentiation | 20 | 0.34 (0.22, 0.46) | 0.145 | 25.4% | Fixed | 12 | 0.15 (0.01, 0.29) | 0.921 | 0% | Fixed |
Neural and prineural invasion | 13 | 0.24 (0.11, 0.36) | 0.002 | 61.1% | Random | 11 | 0.01 (− 0.01, 0.02) | 0.178 | 28.0% | Fixed |
Vascular invasion | 9 | 0.36 (0.17, 0.56) | 0.047 | 50.9% | Random | 2 | 0.24 (− 0.14, 0.62) | 0.339 | 0.0% | Fixed |
TNM | 30 | 0.07 (− 0.15, 0.29) | 0.000 | 76.4% | Random | – | – | – | – | – |
Stage | 15 | 0.10 (− 0.00, 0.19) | 0.000 | 69.8% | Random | 4 | 0.48 (0.26, 0.70) | 0.004 | 77.9% | Random |