Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

Table 3 The co-expression analysis was performed between LYRM4 and the proteins involved in mitochondrial Fe/S protein assembly and export at transcript levels in LIHC using GEPIA2 web

Gene A	Gene B	LIHC tumor		LIHC normal		Liver
Gene A	Gene B	p-value	R	p-value	R	p-value	R
LYRM4	ISCU	0.011	0.13	9e–08	0.67	0	0.71
	NFU1	0	0.45	3.5e–08	0.69	0	0.78
	BOLA1	2.1e–11	0.26	0.00098	0.45	2.8e–06	0.43
	BOLA3	0.00024	0.19	0.29	0.15	4.4e–16	0.68
	NFS1	0.022	0.12	0.32	– 0.14	0.08	0.17
	ACP1	3.5e–09	0.3	0.042	0.29	0	0.7
	ISCA1	0.063	0.097	0.015	0.34	0	0.72
	ISCA2	4.7e–08	0.28	2.4e–05	0.56	2.2e–16	0.68
	IBA57	0.32	0.052	0.34	0.14	0.0011	0.31
	FXN	0.024	0.12	0.19	0.19	0.023	0.22
	FDX1L	2.1e–11	0.34	6.3e–07	0.64	2.1e–14	0.65
	FDXR	0.73	0.018	0.0079	0.37	0.0014	0.3
	HSC20	6.4e–06	0.23	0.016	0.34	8.2e–10	0.54
	HSPA9	0.36	– 0.047	0.3	0.15	4.8e–10	0.55
	GLRX5	0.66	–0.023	0.00061	0.47	2.7e–06	0.43
	ABCB7	0.22	0.064	0.025	0.32	1.1e–09	0.54
	NUBPL	0.13	0.079	0.48	0.1	0.14	0.14
	MFRN1	0.81	0.012	0.027	0.31	0.00035	0.33
	MFRN2	0.48	– 0.037	0.73	0.05	0.31	0.098
	POLD1^a	4.4e–16	0.41	3.6e–07	0.65	0	0.74
	PRIM2^a	0	0.5	0.014	0.35	0	0.74

The bold values indicate the significant difference between the two groups of data, and the statistical significance was set at p < 0.05
^aRepresents the key iron-sulphur proteins outside the mitochondria

ISSN: 1475-2867