Fig. 1From: Recent advances of m6A methylation modification in esophageal squamous cell carcinomaBasic mechanism of m6A methylation in RNA. Basic mechanism of m6A. The m6A methylation is catalyzed by the writer complex including METTL3, METTL14, WTAP, VIRMA, RBM15, ZC3H13 and CBLL1. The m6A modification is removed by demethylase FTO or ALKBH5. Reader proteins recognize m6A and determine target RNA natureBack to article page