Table 1 The role of m6A regulator in ESCC
From: Recent advances of m6A methylation modification in esophageal squamous cell carcinoma
m6A modified type | m6A modification related protein | Expression | Occurrence and development of tumor | Study model | Biological Function | Ref. |
|---|---|---|---|---|---|---|
m6A writers | METTL3 | Upregulated | Promote | In vivo: human | The malignant phenotype of ESCC cells was significantly inhibited by down-regulating PI3K/AKT signal pathway | |
m6A erasers | ALKBH5 | Downregulated | Inhibition | – | There is a positive feedback regulation node between miR-193a-3p and ALKBH5 in esophageal cancer cells | [26] |
FTO | Upregulated | Promote | In vitro: KYSE150, Eca-109, TE-1 | Up-regulation of MMP13 promotes cell proliferation and migration in esophageal squamous cell carcinoma | [32] | |
m6A readers | YTHDC2 | Downregulated | Promote | In vitro: HET-1A,TE-9, Eca-109,KYSE150, EC9706 | rs2416282 participates in the risk of esophageal cancer by regulating the expression of YTHDC2 | [31] |
HNRNPA2B1 | Upregulated | Promote | In vitro: HEEpiC, ECA109, TE10 | Promoting the progress of ESCC by up-regulating the expression of fatty acid synthase ACLY and ACC1 | [33] | |
HNRNPC | Upregulated | Promote | - | HNRNPC may be the promoter of ESCA carcinogenesis | [34] |