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Table 1 The role of m6A regulator in ESCC

From: Recent advances of m6A methylation modification in esophageal squamous cell carcinoma

m6A modified type m6A modification related protein Expression Occurrence and development of tumor Study model Biological Function Ref.
m6A
writers
METTL3 Upregulated Promote In vivo: human The malignant phenotype of ESCC cells was significantly inhibited by down-regulating PI3K/AKT signal pathway [30, 31]
m6A
erasers
ALKBH5 Downregulated Inhibition There is a positive feedback regulation node between miR-193a-3p and ALKBH5 in esophageal cancer cells [26]
FTO Upregulated Promote In vitro: KYSE150, Eca-109, TE-1 Up-regulation of MMP13 promotes cell proliferation and migration in esophageal squamous cell carcinoma [32]
m6A readers YTHDC2 Downregulated Promote In vitro: HET-1A,TE-9, Eca-109,KYSE150, EC9706 rs2416282 participates in the risk of esophageal cancer by regulating the expression of YTHDC2 [31]
HNRNPA2B1 Upregulated Promote In vitro: HEEpiC, ECA109, TE10 Promoting the progress of ESCC by up-regulating the expression of fatty acid synthase ACLY and ACC1 [33]
HNRNPC Upregulated Promote - HNRNPC may be the promoter of ESCA carcinogenesis [34]